Low bone mass and osteoporosis in premenopausal women

Abstract

With low frequency, idiophatic low bone mass (ILBM) and secondary (OP2) osteoporosis can be diagnosed in premenospausal. Objective: To analyze characteristics of a premenopausal population. Ninety four preMP medical records of women who consulted our clinic to evaluate bone mineral density (BMD) were reviewed, personal and family history of fractures, BMD (normal up to Z-score -2.0), bone markers, diagnosis and treatment were analyzed. Fourty one/94 (44%) women had abnormal BMD and 18 (44%) of these were diagnosed as ILBM. On 56% the OP was secondary to: pregnancy, anorexia nervosa, vitamin D deficiency, celiac disease, hypercalciuria, normocalcemic hyperparathyroidism, hypothalamic amenorrhea, exogenous hyperthyroidism, corticosteroids and congenital adrenal hyperplasia. Patients with OP2 and ILBM had similar BMD at the lumbar spine and total femur. Sixty one percent with ILBM and 17% with OP2 had family history of fractures. No significant changes in biochemical parameters were observed in both groups. ILBM patients had a tendency of low bone remodeling. ILBM women received treatment with calcium and vitamin D (12), bisphosphonates (6); OP2 patients received: calcium, vitamin D and treatment of the underlying disease. In 56% of premenopausal OP patients causes were identified, hence the importance of your search. Future longitudinal studies are needed to get further insight on this topic.