Marcadores bioquímicos propuestos para el estudio de la sarcopenia

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Silvina Mastaglia


La sarcopenia asociada a la edad es una condición clínica  caracterizada por una disminución en la fuerza, calidad y cantidad
de masa muscular así como también en la función muscular. Un biomarcador se define como una característica que es medible objetivamente y evaluable como indicador de un proceso biológico normal, patológico o respuesta terapéutica a una intervención farmacológica. Los marcadores bioquímicos propuestos para el estudio de la sarcopenia pueden ser categorizados en dos grupos.
El primero de ellos evalúa el estatus musculoesquelético; este panel de marcadores está formado por miostatina/folistatina, procolágeno aminoterminal tipo III e índice de sarcopenia. El segundo grupo de marcadores bioquímicos evalúa factores causales, para lo cual se sugiere medir el factor de crecimiento insulino-símil tipo 1 (IGF-1), dehidroepiandrosterona (DHEAS), cortisol, factores inflamatorios [proteína C reactiva (PCR), interleuquina 6 (IL-6) y factor de necrosis tumoral (TNF-a)]. Las recomendaciones realizadas están basadas en la evidencia científica disponible en la actualidad y la disponibilidad
de la metodología apropiada para cada uno de los biomarcadores.

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Mastaglia S. Marcadores bioquímicos propuestos para el estudio de la sarcopenia. Actual. Osteol. [Internet]. 15 de agosto de 2023 [citado 21 de mayo de 2024];19(1):p. 9-17. Disponible en:


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