Vitamin D, Secretory Leukocyte Protease Inhibitor (SLPI) and obesity in elder women. Preliminary study
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Abstract
Vitamin D has anti-inflammatory actions, increasing the expression of antimicrobial peptides. Low levels of 25hydroxyvitamin D (25OHD) are associated with obesity. Secretory leukocyte protease inhibitor (SLPI) is a non-glycosylated serine protease peptide with antimicrobial and anti-inflammatory activity, which could be associated with obesity and inflammation. Objective: to evaluate the correlation between 25OHD and SLPI in women and its relationship with obesity. Thirty-two postmenopausal women (69±6 years), without conditions or medications that could affect their inflammatory status, were included. Body weight (BW) (kg) and height (m) were measured and body mass index (BMI) was calculated. SLPI (ng/mL) (ELISA) and 25OHD (ng/mL) (RIA) levels were determined. Fat mass (densitometry) (gr) was normalized by BW to obtain percent fat mass (PFM). Results (X±SD): BMI was 30.3±6.9 and PFM was 43.9±9.6. SLIP ranged from 1.9 to 29.7 (13.1±6.8) and 25OHD ranged from 8.2 to 48 ng/mL (22.1±13.7). PFM, but not BMI, negatively correlated with SLIP (r= -0.64, p=0.01) and 25HOD (r= -0.69, p=0.01). SLPI correlated with 25OHD (r= 0.61, p=0.01). For obese women with 25OHD sufficiency, the correlation between both was highly significant (r=0.97; p<0.0001). Conclusions: In addition to favoring the release of antimicrobial peptides, our results showed that adequate 25OHD levels correlate positively with SLIP in obesity. Further studies in a larger population would be necessary to clarify whether this correlation is clinically relevant.
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Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
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