¿Es útil periostina como biomarcador de displasia fibrosa?

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Silvina R. Mastaglia
Diana González
Walter Tetzlaff
Marina S. Bonanno
Rosana Gainotti
Candela Fernández
Dolores Gómez Glorioso
Beatriz Oliveri

Resumen

La displasia fibrosa (DF) es una enfermedad infrecuente del hueso, no hereditaria producida por una mutación somática del gen GNAS. Periostina (Postn) es un novedoso marcador, cuyos niveles séricos se encuentran elevados en los procesos de reparación tisular, enfermedades fibrosas o inflamatorias. Llevamos a cabo un estudio exploratorio caso-control para evaluar la sensibilidad de Postn como biomarcador de DF. Se incluyeron en el estudio 15 pacientes con DF apareados por edad y género con sujetos sanos (controles) en los cuales se evaluó los niveles séricos de Postn en pacientes con DF y controles y según forma de presentación clínica. No observamos diferencias estadísticamente significativas en los niveles séricos de Postn y el grupo control (DF: 51.1±10ng/ml vs. control: 44.2±15ng/ml; p=0.15) como así tampoco por forma clínica de DF (poliostótica: 51.8±9.1ng/ml vs. monostótica: 49.6±13 ng/ml; p=0.66). Posteriormente realizamos un sub-análisis para evaluar los niveles séricos de Postn en los pacientes con DF y antecedentes de fracturas no observando diferencias estadísticamente significativas [fracturados (n=4): 41.2±17ng/ml vs. no fracturados (n=11): 49.9±11 ng/ml; p=0.47]. Por último analizamos la sensibilidad Postn como biomarcador de DF, mostrando este poseer escasa sensibilidad para estimar actividad de la enfermedad [curva ROC; puntos de corte: 39.625 (0.867-0.467)]. En conclusión, los niveles séricos de Postn en nuestra cohorte de pacientes con DF no mostraron diferencias estadísticamente significativas comparadas con el grupo control o por forma clínica de presentación, mostrando una baja sensibilidad como biomarcador de enfermedad.

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Mastaglia SR, González D, Tetzlaff W, Bonanno MS, Gainotti R, Fernández C, Gómez Glorioso D, Oliveri B. ¿Es útil periostina como biomarcador de displasia fibrosa?. Actual. Osteol. [Internet]. 1 de septiembre de 2022 [citado 16 de octubre de 2024];18(1):p. 22-29. Disponible en: https://ojs.osteologia.org.ar/ojs33010/index.php/osteologia/article/view/12
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Wáng YXJ, Che-Nordin N, Deng M, Griffith JF, Leung JCS, Kwok AWL, et al. Elderly males with or without existing osteoporotic vertebral fracture have much lower future vertebral fracture risk than elderly females: the MrOS (Hong Kong) year-4 follow-up spine radiograph study. Osteoporos Int 2019;30(12):2505-14.

Compston JE, McClung MR, Leslie WD. Osteoporosis [Internet]. The Lancet2019;393: 364-76. Available from: http://dx.doi.org/10.1016/s0140-6736(18)32112-3

Barton DW, Behrend CJ, Carmouche JJ. Rates of osteoporosis screening and treatment following vertebral fracture. Spine J 2019;19(3):411-7.

Schnake KJ, Blattert TR, Hahn P, Franck A, Hartmann F, Ullrich B, et al. Classification of Osteoporotic Thoracolumbar Spine Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU) [Internet]. Global Spine Journal 2018;8: 46S–49S. Available from: http://dx.doi.org/10.1177/2192568217717972

Hinde K, Maingard J, Hirsch JA, Phan K, Asadi H, Chandra RV. Mortality Outcomes of Vertebral Augmentation (Vertebroplasty and/or Balloon Kyphoplasty) for Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis. Radiology [Internet] 2020 [cited 2021 Dec 6]; Available from: https://pubs.rsna.org/doi/abs/10.1148/radiol.2020191294

Dong R, Chen L, Gu Y, Han G, Yang H, Tang T, et al. Improvement in respiratory function after vertebroplasty and kyphoplasty.

Int Orthop 2009;33(6):1689-94.

Yang HL, Zhao L, Liu J, Sanford CG Jr, Chen L, Tang T, et al. Changes of pulmonary function for patients with osteoporotic vertebral compression fractures after kyphoplasty.

J Spinal Disord Tech 2007;20(3):221-5.

Krege JH, Kendler D, Krohn K, Genant H, Alam J, Berclaz PY, et al. Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women With Osteoporosis. J Clin Densitom 2015;18(4):506-11.

Ghandhari H, Ameri E, Zabihiyeganeh M, Mohammadpour M, Aghamohammadi J. Predictors of Kyphosis Progression after the Conservative Treatment of Osteoporotic Vertebral Compression Fracture [Internet]., Shafa Orthopedic Journal 2018;5. Available from: http://dx.doi.org/10.5812/soj.70736

Nathan JK, Johnson MA, Waljee JF, Szerlip N, Park P, Oppenlander ME. Association between timing of kyphoplasty and opioid prescribing risk after vertebral fracture. Neurosurg Focus 2020;49(2):E15.

Yue Q, Ma Y, Teng Y, Zhu Y, Liu H, Xu S, et al. An updated analysis of opioids increasing the risk of fractures. PLoS One 2020;15(4):e0220216.

Hargunani R, Le Corroller T, Khashoggi K, Liu DM, Marchinkow LO, Mudri MJ, et al. An overview of vertebroplasty: current status, controversies, and future directions. Can Assoc Radiol J 2012;63(3 Suppl):S11-7.

Tsoumakidou G, Too CW, Koch G, Caudrelier J, Cazzato RL, Garnon J, et al. CIRSE Guidelines on Percutaneous Vertebral Augmentation. Cardiovasc Intervent Radiol 2017;40(3):331-42.

Sahota O, Ong T, Salem K. Vertebral Fragility Fractures (VFF)-Who, when and how to operate. Injury 2018;49(8):1430-5.

Website [Internet]. Available from: Website. Available: : www.aospine.org/classification

Blattert TR, Schnake KJ, Gonschorek O, Gercek E, Hartmann F, Katscher S, et al. Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU) [Internet]. Global Spine Journal 2018;8:50S-55S. Available from: http://dx.doi.org/10.1177/2192568217745823.

Jang HD, Kim EH, Lee JC, Choi SW, Kim K, Shin BJ. Current Concepts in the Management of Osteoporotic Vertebral Fractures: A Narrative Review. Asian Spine J 2020;14(6):898-909.

Rao RD, Singrakhia MD. Painful osteoporotic vertebral fracture. Pathogenesis, evaluation, and roles of vertebroplasty and kyphoplasty in its management. J Bone Joint Surg Am 2003;85(10):2010-22.

Filippiadis DK, Marcia S, Masala S, Deschamps F, Kelekis A. Percutaneous Vertebroplasty and Kyphoplasty: Current Status, New Developments and Old Controversies. Cardiovasc Intervent Radiol 2017;40(12):1815-23.

Deramond H, Depriester C, Toussaint P, Galibert P. Percutaneous Vertebroplasty. Semin Musculoskelet Radiol 1997;1(2):285-96.

Jennings JW. Vertebral Augmentation Is More than Just Pain Palliation, It Is about Improved Mortality. Radiology [Internet] 2020 [cited 2021 Dec 5]; Available from: https://pubs.rsna.org/doi/abs/10.1148/radiol.2020192806.

Mathis JM, Belkoff SM, Deramond H. History and Early Development of Percutaneous Vertebroplasty [Internet]. Percutaneous Vertebroplasty and Kyphoplasty. pp. 3-7. Available from: http://dx.doi.org/10.1007/0-387-36083-2_1.

Gangi A, Guth S, Imbert JP, Marin H, Dietemann JL. Percutaneous Vertebroplasty: Indications, Technique, and Results1. Radiographics [Internet] 2003 [cited 2021 Dec 5]; Available from: https://pubs.rsna.org/doi/abs/10.1148/rg.e10.

Pua U, Lim GHT. Cone-Beam CT-Guided Vertebroplasty in a Patient with Vertebra Plana. AJR Am J Roentgenol 2016;207(1):196-9.

Burton AW, Rhines LD, Mendel E. Vertebroplasty and kyphoplasty: a comprehensive review [Internet]. Neurosurgical Focus 2005;18: 1-9. Available from: http://dx.doi.org/10.3171/foc.2005.18.3.2.

Dohm M, Black CM, Dacre A, Tillman JB, Fueredi G, KAVIAR investigators. A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis. AJNR Am J Neuroradiol 2014;35(12):2227-36.

Clark W, Bird P, Gonski P, Diamond TH, Smerdely P, McNeil HP, et al. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2016;

(10052):1408-16.

Saracen A, Kotwica Z. Complications of percutaneous vertebroplasty: An analysis of 1100 procedures performed in 616 patients. Medicine 2016;95(24):e3850.

Kozima S, de Salazar A, Espil G, Siffredi C, Ferrari L, Mora C, et al. Vertebroplastia percutánea guiada por tomografía para el manejo del dolor en pacientes con fractura del cuerpo vertebral [Internet]. Vol. 82, Revista Argentina de Radiología / Argentinian Journal of Radiology. 2018;82:002-12. Available from: http://dx.doi.org/10.1055/s-0038-1637029.

Seong JY, Kim JS, Jung B, Lee SH, Kang HY. CT-guided percutaneous vertebroplasty in the treatment of an upper thoracic compression fracture. Korean J Radiol 2009;10(2):185-9.

Klazen CAH, Lohle PNM, de Vries J, Jansen FH, Tielbeek AV, Blonk MC, et al. Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 2010;

(9746):1085-92.

Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 2009;361(6):569-79.

Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 2009;361(6):557-68.

Al-Nakshabandi NA. Percutaneous vertebroplasty complications. Ann Saudi Med 2011;31(3):294-7.

Komemushi A, Tanigawa N, Kariya S, Kojima H, Shomura Y, Komemushi S, et al. Percutaneous vertebroplasty for osteoporotic compression fracture: multivariate study of predictors of new vertebral body fracture. Cardiovasc Intervent Radiol 2006;29(4):580-5.

Kim YJ, Lee JW, Park KW, Yeom JS, Jeong HS, Park JM, et al. Pulmonary cement embolism after percutaneous vertebroplasty in osteoporotic vertebral compression fractures: incidence, characteristics, and risk factors. Radiology 2009;251(1):250-9.

Krueger A, Bliemel C, Zettl R, Ruchholtz S. Management of pulmonary cement embolism after percutaneous vertebroplasty and kyphoplasty: a systematic review of the literature. Eur Spine J 2009;18(9):1257-65.

Venmans A, Lohle PNM, van Rooij WJ, Verhaar HJJ, Mali WPT. Frequency and Outcome of Pulmonary Polymethylmethacrylate Embolism during Percutaneous Vertebroplasty. AJNR Am J Neuroradiol 2008;29(10):1983-5.

Mathis JM. Percutaneous vertebroplasty: complication avoidance and technique optimization. AJNR Am J Neuroradiol 2003;24(8):1697-706.

Xing D, Ma JX, Ma XL, Wang J, Xu WG, Chen Y, et al. A meta-analysis of balloon kyphoplasty compared to percutaneous vertebroplasty for treating osteoporotic vertebral compression fractures [Internet]. J Clin Neurosci 2013;20: 795-803. Available from: http://dx.doi.org/10.1016/j.jocn.2012.05.038.

Movrin I, Vengust R, Komadina R. Adjacent vertebral fractures after percutaneous vertebral augmentation of osteoporotic vertebral compression fracture: a comparison of balloon kyphoplasty and vertebroplasty. Arch Orthop Trauma Surg 2010;130(9):1157-66.

Chandra RV, Maingard J, Asadi H, Slater LA, Mazwi TL, Marcia S, et al. Vertebroplasty and Kyphoplasty for Osteoporotic Vertebral Fractures: What Are the Latest Data? AJNR Am J Neuroradiol 2018;39(5):798-806.

Rodríguez AJ, Fink HA, Mirigian L, Guañabens N, Eastell R, Akesson K, et al. Pain, Quality of Life, and Safety Outcomes of Kyphoplasty for Vertebral Compression Fractures: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res 2017;32(9):1935-44.

Ebeling PR, Akesson K, Bauer DC, Buchbinder R, Eastell R, Fink HA, et al. The Efficacy and Safety of Vertebral Augmentation: A Second ASBMR Task Force Report. J Bone Miner Res 2019;34(1):3-21.

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