Negative association between 25-hydroxyvitamin D and inflammatory markers in rheumatologic diseases
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Abstract
Objective
The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with inflammatory markers in patients with rheumatologic diseases (RD).
Methods
A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out.
Results
No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG.
The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD
deficiency compared to RD (29.9% vs 53.2%).
The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG.
25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were significantly and negatively associated with 25OHD levels through linear regression analysis. According
to univariate logistic regression analysis for 25OHD deficiency (<20 ng/ml), a significant and negative association with BMI, presence of RD, ESR and CRP were found.
Conclusion
Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D deficiency. In addition, 25OHD has a negative correlation with ESR and CRP as inflammatory markers.
Article Details
Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
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