Guidelines for the diagnosis, prevention and treatment of glucocorticoid-induced osteoporosis in adults

Abstract

Glucocorticoid induced osteoporosis (GIO) is the most common cause of secondary osteoporosis. It occurs early, with rapid bone loss in the few weeks after the initiation of the treatment, with a rate that is dependent mainly on the daily dose. The pathogenesis is multifactorial, the highest inhibitory effect occurs on bone formation. Glucocorticoids induce fragility fractures, especially in spine, generating functional disability. In recent years there have been some international guidelines developed by consensus for the prevention and treatment of GIO. The Argentine Osteoporosis Society appointed a working group to prepare a national guide updating the diagnosis, prevention and treatment of GIO.