High frequency of fragility fractures in postmenopausal women with dysmobility syndrome: a single-center cross-sectional study
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Abstract
Purpose: To assess the frequency of dysmobility syndrome (DS) in a group of postmenopausal women, to determine the frequency of fragility fractures in these patients, and to compare the frequency of fragility fractures and other clinical, biochemical, densitometric, and muscle health characteristics between patients with and without DS.
Methods: Postmenopausal women aged ≥ 60 years were invited to participate in a muscle health study program in our bone clinic. The diagnosis of DS was considered when at least three of the following factors were present: osteoporosis, ≥ 1 fall in the preceding year, low muscle mass, slow gait speed, low grip strength, and high-fat mass. The cohort was divided into patients with DS and without DS.
Results: The mean age in the study cohort (n = 250) was 70.36± 7.72 years. DS was diagnosed in 77 patients (30.8 %). A history of falls in the preceding year and the prevalence of fragility fractures were more frequent in patients with DS in comparison with the control group (60% vs. 19%, p ˂ 0.001 and 42% vs 17%, p < 0.001, respectively). Furthermore, the history of fragility fractures was significantly associated with the presence of DS (OR 4.92, 95% CI 2.3-10.4, p <0.001).
Discussion: A significant association was found between DS and a history of fragility fractures. Although this new concept needs further investigation, it seems that the identification of various compartments affected by the aging process results in an opportunity to better predict major adverse events in the elderly.
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Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
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