Vitamin D and Pregnancy: a pilot experience
Article Sidebar
Main Article Content
Abstract
Vitamin D (VD) insufficiency in pregnancy is associated with a higher incidence of cesarean section, preeclampsia, and preterm delivery. Objective: to evaluate if the degree of VD insufficiency is associated with the incidence of cesarean section and to determine the correlation between maternal and newborn cord blood 25-hydroxy VS (25OHD). Women (n=127) were divided according to their 25OHD levels (ng/mL): G1:<20 (deficiency), G2:20-30 (insufficiency), G3:>30 (sufficiency). Age; gestational age (GA); body mass index (BMI); systolic and diastolic blood pressure (mmHg); type of delivery and the season of the year in which the sample was taken were recorded. Calcemia (ng/mL); 25OHD; intact parathormone (pg/mL); bone alkaline phosphatase (IU/L) and Crosslaps (pg/mL) levels were determined. Mean age was 26±6 years and GA was 35.8±2.7 weeks with no differences among groups. The % of cesarean sections was higher in G1 than in G2 and G3 (31.3%, 21.4% and 25%; p<0.05). The highest % of samples were taken in spring (p<0.05). No differences were observed in the other maternal variables studied. Maternal serum 25OHD levels correlated positively with those of cord blood from their respective newborns (r=0.67; p<0.0001). Regardless the season of the year and BMI, a high % of the studied pregnant women presented 25OHD levels lower than 30 ng/ml. Conclusion: we found that maternal VD deficiency is associated with the number of cesarean sections. In addition, 25OHD levels in the newborn significantly correlate with maternal serum levels.
Article Details
Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
References
Sánchez A, Oliveri M B, Mansur J L, Fradinger E, Mastaglia SR. Guía de la federación argentina de sociedades de endocrinología sobre diagnóstico, prevención y tratamiento de la hipovitaminosis D. Actual Osteol 2015;11(2):151-71.
Al-Khalidi B, Kimball SM, Kuk JL, Ardern CI. Metabolically healthy obesity, vitamin D, and all-cause and cardiometabolic mortality risk in NHANES III. Clin Nutr 2019;38(2):820-8. doi:10.1016/j.clnu.2018.02.025
Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. doi:10.1002/14651858.CD011511.pub3
Plantone D, Primiano G, Manco C, Locci S, Servidei S, De Stefano N. Vitamin D in Neurological Diseases. Int J Mol Sci 2022;24(1):87. Published 2022 Dec 21. doi:10.3390/ijms24010087
Pittas AG, Kawahara T, Jorde R, et al. Vitamin D and Risk for Type 2 Diabetes in People with Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data from 3 Randomized Clinical Trials. Ann Intern Med 2023;176(3):355-63. doi: 10.7326/M22-3018.
Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, et al Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review. Front Immunol 2023;14:950465. doi: 10.3389/fimmu.2023.950465.
Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR. Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children. Nutrients 2022;14(9):1900. doi: 10.3390/nu14091900.
Morales-Suárez-Varela M, Uçar N, Soriano JM, Llopis-Morales A, Sanford BS, Grant WB. Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis. Nutrients 2022;14(19):4124. doi:10.3390/nu14194124
Wong RS, Tung KTS, Mak RTW, et al. Vitamin D concentrations during pregnancy and in cord blood: a systematic review and meta-analysis. Nutr Rev 2022;80(12):2225-36. doi:10.1093/nutrit/nuac023
Luo T, Lin Y, Lu J, Lian X, Guo Y, Han L, Guo Y. Effects of vitamin D supplementation during pregnancy on bone health and offspring growth: A systematic review and meta-analysis of randomized controlled trials. PLoS One 2022;17(10):e0276016. doi: 10.1371/journal.pone.0276016.
Zhang H, Wang S, Tuo L, Zhai Q, Cui J, Chen D, Xu D. Relationship between Maternal Vitamin D Levels and Adverse Outcomes. Nutrients 2022;14(20):4230. doi: 10.3390/nu14204230.
Palacios C, Kostiuk LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2019;7(7):CD008873. doi:10.1002/14651858.CD008873.pub4
Oliveri B, Mautalen C, Alonso A, y cols. Estado nutricional de vitamina D en madres y neonatos de Ushuaia y Buenos Aires. Medicina 1993;53:315-20.
Tau C, Bonifacino MM, Scaiola E y cols. Niveles circulantes de 25 hidroxivitamina D en población materno-infantil de zonas de riesgo del país: Provincias de Chubut, Santa Cruz y Tierra del Fuego. Med Infant 2004; XI: 199-204.
Brito GM, Mastaglia SR, Goedelmann C, Seijo M, Somoza J, Oliveri B. Exploratory study of dietary intake and prevalence of vitamin D deficiency in women > 65 years old living in their family home or in public homes of Buenos Aires city, Argentina. Nutr Hosp [Internet]. 2013; 28( 3 ): 816-22.
Aydogmus S, Kelekci S, Aydogmus H, Demir M, Yilmaz B, Sutcu R. Association of antepartum vitamin D levels with postpartum pelvic floor muscle strength and symptoms. Int Urogynecol J 2015;26(8):1179-84. doi:10.1007/s00192-015- 2671-3
Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab 2009;94(3):940-5. doi: 10.1210/jc.2008-1217.
Yuan Y, Liu H, Ji C, Guo X, Hu L, Wen J, Cai M. Association of Maternal Serum 25-hydroxyvitamin D Concentrations in Second Trimester with Delivery Mode in A Chinese Population. Int J Med Sci 2017;14(10):1008-14. doi: 10.7150/ijms.20337.
Amiri M, Rostami M, Sheidaei A, Fallahzadeh A, Ramezani Tehrani F. Mode of delivery and maternal vitamin D deficiency: an optimized intelligent Bayesian network algorithm analysis of a stratified randomized controlled field trial. Sci Rep 2023;13(1):8682. doi: 10.1038/s41598-023-35838-6.
Giacoia E, Costanzo PR, Mansur J. Variación estacional de los niveles de vitamina D y su relación con la obesidad en una población de embarazadas de alto riesgo en Buenos Aires. Rev Argent Endocrinol Metab 2019;56(4): 327-32.
Treiber M, Mujezinović F, Pečovnik Balon B, Gorenjak M, Maver U, Dovnik A. Association between umbilical cord vitamin D levels and adverse neonatal outcomes. J Int Med Res 2020;48(10):300060520955001. doi: 10.1177/0300060520955001.
van der Pligt P, Willcox J, Szymlek-Gay EA, Murray E, Worsley A, Daly RM. Associations of Maternal Vitamin D Deficiency with Pregnancy and Neonatal Complications in Developing Countries: A Systematic Review. Nutrients 2018;10(5):640. doi: 10.3390/nu10050640.