Parathyroid carcinoma. Description of a clinical case

Abstract

Parathyroid carcinoma is a rare entity that accounts for <1% of patients with primary hyperparathyroidism. The incidence of this pathology is extremely low even with increased hyperparathyroidism diagnosed after the determination of serum calcium became more frequent. The measurement of parathyroid hormone (PTH) and calcium levels postoperatively are useful, since normal values indicate successful surgery while the persistence of high levels of PTH and calcium levels after parathyroidectomy forces us to suspect metastatic disease. A 52 year-old male with primary hyperparathyroidism diagnostic presented anorexia, generalized fatigue, constipation, nausea, vomiting, polyuria, polydipsia, musculoskeletal pain, irritability one week of evolution. Serum calcium levels were >14 mg/dl and PTH ten times above normal maximum. After surgery histopathological and immunohistochemical features were compatible with parathyroid cancer. After surgery showed good clinical progress with periodic monitoring of serum calcium and PTH within normal parameters. No evidence of local recurrence or distant was observed having a total evolution of 5 years from their first admission.