Bioactive Glass in Osteology: Emerging Benefits, Safety, and Potential Applications in Orthopedic Surgery
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Abstract
Bioactive glass is an emerging biomaterial in orthopedic surgery due to its biocompatibility, antimicrobial effect, and osteogenic capacity. It shows benefits in osteomyelitis and bone defects, reducing antibiotic use. However, robust clinical studies are needed to define its role in routine practice.
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References
Ren Z, Tang S, Wang J, et al. Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations. Biomater Res [Internet]. 2025;29:0134. Disponible en: http://dx.doi.org/10.34133/bmr.0134.
Workie AB, Shih SJ. A study of bioactive glass-ceramic's mechanical properties, apatite formation, and medical applications. RSC Adv [Internet]. 2022;12(36):23143-52. Disponible en: http://dx.doi.org/10.1039/d2ra03235j.
Van Vugt TAG, Heidotting J, Arts JJ, Ploegmakers JJW, Jutte PC, Geurts JAP. Mid-term clinical results of chronic cavitary long bone osteomyelitis treatment using S53P4 bioactive glass: a multi-center study. J Bone Jt Infect [Internet]. 2021;6(9):413-21. Disponible en: http://dx.doi.org/10.5194/jbji-6-413-2021.
Kwon BT, Kim HJ, Lee S, et al. Feasibility and safety of a CaO-SiO2-P2O5-B2O3 bioactive glass ceramic spacer in posterior lumbar interbody fusion compared with polyetheretherketone cage: a prospective randomized controlled trial. Acta Neurochir (Wien) [Internet]. 2023;165(1):135-44. Disponible en: http://dx.doi.org/10.1007/s00701-022-05429-x.
Gatti SD, Gaddi D, Turati M, et al. Clinical outcomes and complications of S53P4 bioactive glass in chronic osteomyelitis and septic non-unions: a retrospective single-center study. Eur J Clin Microbiol Infect Dis [Internet]. 2024;43(3):489-99. Disponible en: http://dx.doi.org/10.1007/s10096-023-04737-z.
Xu H, Zhu Y, Xu J, et al. Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing. Bioeng Transl Med [Internet]. 2022;8(1):e10345. Disponible en: http://dx.doi.org/10.1002/btm2.10345.
Hung GY, Wang CY, Feng KC, et al. Manipulating Mg/Ca ratios in MgO-CaO-SiO2 bioactive glass for achieving accelerated osteogenic differentiation of human adipose-derived stem cells. BiomaterAdv [Internet]. 2025;169:214189. Disponible en: http://dx.doi.org/10.1016/j.bioadv.2025.214189.
Schmidt V, Polgár B, Nemes VÁ, et al. Interaction of MG63 Human Osteosarcoma-Derived Cells on S53P4 Bioactive Glass: An In Vitro Study. J Funct Biomater [Internet]. 2025;16(8):275. Disponible en: http://dx.doi.org/10.3390/jfb16080275.
Lozada-Martínez ID, Hernández-Páez D, Zárate YEJ, Delgado P. Scientometrics and meta-research in medical research: approaches required to ensure scientific rigor in an era of massive low-quality research. Rev Assoc Med Bras (1992) [Internet]. 2025;71(4):e20241612. Disponible en: http://dx.doi.org/10.1590/1806-9282.20241612.
Lozada-Martínez ID, Neira-Rodado D, Martínez-Guevara D, Cruz-Soto HS, Sánchez-Echeverry MP, Liscano Y. Why is it important to implement meta-research in universities and institutes with medical research activities? Front Res Metr Anal [Internet]. 2025;10:1497280. Disponible en: http://dx.doi.org/10.3389/frma.2025.1497280.