Metabolic syndrome, metformin and bone

Main Article Content

Nahuel E. Wanionok
Antonio D. McCarthy

Abstract

Metabolic syndrome is de!ned as a heterogeneous and multifactorial disorder with high cardiovascular risk. Its incidence is currently growing due to sedentary lifestyles and diets with a high intake of fats and sugars.
Treatment for metabolic syndrome begins with changes in lifestyle, such as physical activity and a healthy and hypocaloric diet. When this is not effective, different drugs can be used, and one of the most frequently prescribed is
the insulin-sensitizer metformin.
Numerous investigations have evaluated the possible link between metabolic syndrome and alterations in bone metabolism. Although not conclusive, most clinical studies point to an association between metabolic syndrome, a decrease in bone mineral density and an increase in the incidence of osteoporotic
fractures. However, an important limitation of these studies is the great heterogeneity of individuals with metabolic syndrome. In view of preclinical research indicating possible osteogenic actions of metformin, the effects on bone of metformin has been evaluated in patients with hyperglycemia. Most studies have found either no effect on fracture incidence, or a mild protective action. However, since elevated concentrations of metformin might negatively affect bone metabolism, caution should be taken when prescribing this drug for
patients who require high doses, and/or have an excess fracture risk.

Article Details

How to Cite
1.
Wanionok NE, McCarthy AD. Metabolic syndrome, metformin and bone. Actual. Osteol. [Internet]. 2023 May 31 [cited 2024 Nov. 22];18(3):p. 169-182. Available from: https://ojs.osteologia.org.ar/ojs33010/index.php/osteologia/article/view/68
Section
Reviews

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