The effect of erythropoietin on acid phosphatase levels during ischemia reperfusion injury in rats

Abstract

Although the usage of erythropoietin (EPO) in ischemia reperfusion (IR) is known, the speed of administration, dose and time of suitable administration are not so well-known. The aim of this work was to study the effect of erythropoietin (EPO) on bone damage induced by ischemia and reperfusion studied by changes on blood acid phosphatase (ACP) levels in rats. ACP was measured at these time points: 60 min after reperfusion (groups A and C), and 120 min after reperfusion (groups B and D), A and B without but C and D with EPO administration. Results: EPO administration non significantly increased the ACP levels. Reperfusion time non significantly increased the ACP levels and the interaction of EPO administration and reperfusion time non significantly increased the ACP levels. Conclusions are that EPO administration does not attenuate the osteoclastic bone action of ischemia within narrow context of 2 hours. Perhaps, a longer study may prove a reverse beneficial action for ACP values.