Statins and bone health: a mini review

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Published: Jun 29, 2024
Keywords:
statins bone loss fracture healing

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Leslie R. Morse
Rocky Mountain Regional Spinal Injury System, Craig Rehabilitation Hospital, Englewood, Colorado, United States of America. Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, United States of America
Jennifer Coker
1 Rocky Mountain Regional Spinal Injury System, Craig Rehabilitation Hospital, Englewood, Colorado, United States of America
Ricardo A. Battaglino
2 Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, United States of America

Abstract

Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs.
Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteoprotective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.

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How to Cite
1.
Morse LR, Coker J, Battaglino RA. Statins and bone health: a mini review. Actual. Osteol. [Internet]. 2024 Jun. 29 [cited 2024 Oct. 5];14(1):31-5. Available from: https://ojs.osteologia.org.ar/ojs33010/index.php/osteologia/article/view/185
Issue
Vol. 14 No. 1 (2018): Actualizaciones en Osteología
Section
Reviews

Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.