Obtaining, characterization and biocompatibility of polymeric hydrogels for Tissue Engineering.
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Abstract
Tissue engineering is an interdisciplinary science that is constantly searching for materials that can help repair damaged tissue, in our case, bone and cartilage tissue. In this work, we obtained a biomaterial using sodium alginate (natural polymer) and synthetic cationic polyelectrolyte (PEC) produced in our laboratories. The union of both polymers, given by ionic forces, was increased thanks to the application of ultrasound. When we evaluated the in-vitro toxicity of the biomaterials using RAW 264.7 macrophage cells, we found that the application of ultrasound produced a non-toxic material compared to when this technology is not applied, in addition to a greater capacity to promote the proliferation of MC3T3-E1 preosteoblastic cells and chondrocytic cells grown on them. Although additional experiments need to be carried out, our Alginate-PEC biomaterial with ultrasound turns out to be promising to be used as scaffolds in bone and cartilage tissue engineering.
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Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
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