Obtención, caracterización y biocompatibilidad de hidrogeles poliméricos para Ingeniería de Tejidos.
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Resumen
Ingeniería de tejido es una ciencia interdisciplinaria que se encuentra en constante búsqueda de materiales que puedan ayudar a reparar el tejido dañado, en nuestro caso, tejido óseo y cartilaginoso. En este trabajo, obtuvimos un biomaterial utilizando alginato de sodio (polímero natural) y polielectrolito catiónico sintético (PEC) producido en nuestros laboratorios. La unión de ambos polímeros dada por fuerzas iónicas, se vio incrementada gracias a la aplicación de ultrasonido. Cuando evaluamos la toxicidad in-vitro de los biomateriales utilizando células macrofágicas RAW 264.7, encontramos que la aplicación de ultrasonido produjo un material no toxico en relación a cuando esta tecnología no se aplica, además de una mayor capacidad de fomentar la proliferación de células preosteoblasticas MC3T3-E1 y células condrocíticas crecidas sobre ellos. Si bien, hace falta realizar experimentos adicionales, nuestro biomaterial Alginato-PEC con ultrasonido resulta ser prometedor para ser utilizado como scaffolds en Ingeniería de tejido óseo y cartilaginoso.
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Derechos de autor: Actualizaciones en Osteología es la revista oficial de la Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) que posee los derechos de autor de todo el material publicado en dicha revista.
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