Tumor pardo del paladar, presentación atípica de hiperparatiroidismo primario en adolescente. Buena evolución y normalización de la masa ósea tras paratiroidectomía

Contenido principal del artículo

Cristina Tau
Emilia Vaca
Gabriel Damiano
Florencia Soto
Francisco Arakaki
Diego Rosso

Resumen

El hiperparatiroidismo primario (HPTP) es poco frecuente en niños y adolescentes. Hay escasos datos para el manejo de estos pacientes en pediatría. Las glándulas paratiroideas son glándulas endocrinas que secretan hormona paratiroidea (PTH) y regulan el metabolismo del calcio y del fósforo. La sobreexpresión de PTH se llama hiperparatiroidismo y este se clasifica en primario, secundario y terciario. En los adolescentes, 80 to 92% de los hiperparatiroidismos primarios se deben a adenoma paratiroideo. Su desarrollo es infrecuente durante la adolescencia. Presentamos el caso clínico de una adolescente con una primera manifestación atípica de HPTP con presencia de un tumor pardo del paladar, presentación rara de adenoma paratiroideo, acompañado de hipercalcemia, marcada elevación de PTH y varias lesiones óseas.

Detalles del artículo

Cómo citar
1.
Tau C, Vaca E, Damiano G, Soto F, Arakaki F, Rosso D. Tumor pardo del paladar, presentación atípica de hiperparatiroidismo primario en adolescente. Buena evolución y normalización de la masa ósea tras paratiroidectomía . Actual. Osteol. [Internet]. 7 de noviembre de 2022 [citado 26 de abril de 2024];17(1):p. 45-56. Disponible en: https://ojs.osteologia.org.ar/ojs33010/index.php/osteologia/article/view/59
Sección
Reporte de casos

Citas

Hsu S, Levine M. Primary hyperparathyroidism in children and adolescents: The Johns Hopkins Children’s Center experience. J Bone Miner Res 2002;17:N44-N50.

. Rampp RD, Mancilla EE, Adzick NS, et al. Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and Adolescents. World J Surg 2020;44:1518-25.

Kordahi AM, Newfield RS, Bickler SW, et al. Undescended retropharyngeal parathyroid adenoma with adjacent thymic tissue in a 13-year-old boy with primary hyperparathyroidism Oxford Medical Case Reports 2019;12:519-23.

Eric Mallet Working Group on Calcium Metabolism. Primary Hyperparathyroidism in Neonates and Childhood. The french experience (1984-2004). Horm Res 2008;69:180-8.

Kollars J, Zarroug AE, Van Heerden J, et al. Primary Hyperparathyroidism in Pediatric Patients. Pediatrics 2005;115:974-80.

Zou H, Song L, Jia M, Wang L, Sun Y. Brown tumor of multiple facial bones associated with primary hyperparathyroidism A clinical case report. Medicine (Baltimore) 2018; 97:e11877.

Harman CR, Van Heerden JA, Farley DR, et al. Sporadic primary hyperparathyroidism in young patients: a separate disease entity? Arch. Surg 1999;134:651-6.

Bhadada SK, Bhansali A, Dutta P, Behera A, Chanukya GV, Mittal BR. Characteristics of Primary Hyperparathyroidism in Adolescents. J Pediatric Endocrinol Metabolism 2008; 21:1147-53.

Venail F, Nicollas R, Morin D, et al. Solitary Parathyroid Adenoma: A Rare Cause of Primary Hyperparathyroidism in Children. Laryngoscope 2007;117:946-9.

Pemberton J de J, Geddie KB. Hyperparathyroidism. Ann Surg 1930; 92:202-11.

Belcher R, Metrailer AM, Bodenner DL,. Stack Jr. BC. Characterization of hyperparathyroidism in youth and adolescents: A literature review. Int J Pediatr Otorhinolaryngol 2013;77:318-22.

Aslan S, Bilgici MC, Bernay RF, Aydin HM, Selcuk MB. Parathyroid adenoma presenting with multiple Brown tumors in an adolescent patient. North Clin Istanb 2018;5:361-4.

Pashtan I, Grogan RH,. Kaplan SP, et al. Primary hyperparathyroidism in adolescents: the same but different. Pediatr Surg Int 2013;29:275-9.

Cronin CS, Reeve TS, Robinson B, Clifton-Bligh P, Guinea A, Delbridges L. Primary hyperparathyroidism in childhood and adolescence J. Paediatr. Child Health 1996;32:397-9.

Nicholson KJ, McCoy KL, Witchel SF, Stang MT, Carty SE, Yip L. Comparative characteristics of primary hyperparathyroidism in pediatric and young adult patients. Surgery 2016;160:1008-16.

Roizen J, Levine MA. Primary hyperparathyroidism in children and adolescents. J Chin Med Assoc 2012;75:425.34.

Lawson ML, Miller SF, Ellis G, et al. Primary hyperparathyroidism in a paediatric hospital. QJM 1996; 89:921-32.

Mancilla EE, Levine MA, Adzick NS. Outcomes of minimally invasive parathyroidectomy in pediatric patients with primary primary hyperparathyroidism owing to parathyroid adenoma: a single institution experience. J Pediatr Surg 2017;52:188-91.

Atabek ME, Pirgon O, Sert A, Esen HH. Extensive brown tumors caused by parathyroid adenoma in an adolescent patient. Eur J Pediatr 2008;167:117-9.

Wang X, Wang M, Zhang J, et al. Humeral brown tumor as first presentation of primary hyperparathyroidism caused by ectopic parathyroid adenomas: report of two cases and review of literature Int J Clin Exp Pathol 2014;7:7094-9.

Eklioglu BS, Atabek ME, Akyürek N, et al. Parathyroid adenoma presented with multiple brown tumors and nephrocalcinosis. J Pediatr Endocrinol Metab 2013;26:213-4.

Guney E, Yigitbasi O.G, Ozer V, Canoz O. Brown tumor of the maxilla associated with primary hyperparathyroidism. Auris Nasus Larynx 2001;28:369-72.

De Pablos PL, Ramos I, De La Calle H. Brown tumor in the palate associated with primary hyperparathyroidism. J Oral Maxillofac Surg 1987; 45:719-20.

Daniels JS. Primary hyperparathyroidism presenting as a palatal brown tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98:409-13.

-Scott S N, Graham SM, Sato Y, Robinson RA. Imaging case study of the month. Brown tumor of the palate in a patient with primary hyperparathyroidism. Ann Otol Rhinol Laryngol 1999;108:91-4.

Zivaljevic V, Jovanovic M, Diklic A, Zdravkovic V, Djordjevic M, Paunovic I. Differences in primary hyperparathyroidism characteristics between children and adolescents. J Pediatr Surg 2020; 55:1660-2.

Taillefer R, Boucher Y, Potvin C, Lambert R. Detection and localization of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with technetinum-99m-sestamibi (double-phase study). J Nucl Med 1992;33:1801-7.

Gillis D, Hirsch Hj, Landau H, Schiller M, Lebensart PD, Peylan-Ramu N. Parathyroid adenoma after radiation in an 8-year-old boy. J Pediatr 1998; 132:892-3.

Garabedian M, Holick MF, DeLuca HF, Boyle IT. Control of 25-Hydroxycholecalciferol Metabolism by Parathyroid Glands. Proc. Nat. Acad. Sci. USA 1972;69:1673-6.

Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism. Lancet 2018;391:168-78.

Tau C, Viterbo G, Ayarzabal V, Felipe L, Belgorosky A. Rapid Bone Mass Recovery after Parathyroidectomy for Primary Hyperparathyroidism in a 15-year-old Boy. Bone Abstracts 6th International Conference on Children Bone Health (ICCBH), Rotterdam June 2013; Volume 2 ISSN 2052-1219 (online).DOI:10.1530/boneabs.2.P101.

Vanstone MV, Udelsman RD, Cheng DW, Carpenter TO. Rapid Correction of Bone Mass after Parathyroidectomy in an Adolescent with Primary Hyperparathyroidism. J Clin Endocrinol Metab 2011;96:E347-E350.